Heart and Circulatory System II
Daphne T. Hsu, MD
dh17@columbia.edu

Review
Venous return (systemic and pulmonary)
Formation of the primitive ventricles
Atrial septation

Outline
Atrioventricular septation: formation of the atrioventricular valves
Ventricular septation
Conotruncal septum
Membranous septum
Development of the great arteries
Transition from fetal to neonatal circulation
Congenital heart defects

Formation of Primitive Ventricles

Atrial Septation: Endocardial Cushion Formation

Atrioventricular Valve Formation

Week 12

Conotruncal septation
Septation of the truncus arteriosus
Aorta
Pulmonary artery
Ventricular septation
Conotruncal septum

Conotruncal Septation

Formation of the Aorta and Pulmonary Artery

Formation of the Conotruncal Septum

Conotruncal Formation

Ventricular Septum

Semilunar Valve Formation

Formation of the Aortic Arch

Formation of the Aortic Arch

Fetal Circulation

Neonatal Circulation

Transition from Fetal to Neonatal Circulation

Atrial Septal Defects

Slide 21

Slide 22

Slide 23

Slide 24

Chromosome 22q11 Microdeletion