| CASPASES |
| • FAMILY OF EXECUTORS OF APOPTOTIC DEATH |
| • CYSTEINE PROTEASES THAT CLEAVE AFTER ASP |
| • CONSTITUTIVELY PRESENT AS INACTIVE FORMS |
|
|
| • ACTIVATED BY CLEAVAGE OR BY INTERACTION
WITH |
|
| COFACTORS SUCH AS APAF1 AND
CYTOCHROME C |
|
|
|
| • WHEN ACTIVATED, CLEAVE CELLULAR
SUBSTRATES, |
|
| LEADING TO APOPTOTIC DEATH |
|