The ENS is a unique part of the nervous system
Mediates behavior of gut in absence of input from CNS.
Most neurons not connected to CNS
Lacks internal collagen
Support from enteric glia
Many neurons and many types of neuron
Every class of neurotransmitter found in CNS is also in ENS
More neurons than spinal cord
More neurons than remainder of PNS
Greatest phenotypic diversity in PNS