•Signals from the environment received by crest
cells regulate their:
–migratory paths
–proliferation
–restriction of developmental potential
–survival
–formation of terminally differentiated derivatives.
•As crest-derived cells migrate they change:
–cell surface receptors
–intracellular transduction mechanisms.
•Postmigratory cells in the gut are thus different
from their premigratory precursors
in the neural crest.