•The endothelins are vasoactive peptides
–edn1 (ET-1), edn2 (ET-2), edn3 (ET-3)
•Big endothelins are secreted and converted in tissues to active
peptides by endothelin converting enzymes (1 and 2).
•There are 2 endothelin receptors.
•Ednra (ETA) and Ednrb
(ETB).
–edn1 and edn2 stimulate both
–edn3 only activates Ednrb.
•ENS development requires edn3 and ednrb.