The terminal colon is normally colonized in
end3
ls
<> WT chimeric mice
•
Cell of WT mice have low and
end3
ls
mice have high levels of
b
-
glucuronidase
•
Crypts are clonal in origin.
•
Neurons and connective tissue cells are either WT or
edn3
ls
.
•
Edn3
ls
neurons are found in the terminal colon.