Specific transcription and growth factors define
stages in ENS development
Phox2b
Ret/GFR
a
1/GDNF
Glia
Ret+
Mash-1
5-HT, NOS
Uncommitted progenitor (vagal/sacral crest)
Ret-, Sox10
+
Mash-1
TrkC/NT-3
TC cells
CGRP, subm IPANs
Sox 10
Esophagus only