Crest-derived cells migrate in the outer gut
mesenchyme; the submucosal plexus forms
secondarily.
•
Vagal crest-derived cells
migrate proximo-distally
down the bowel in its outer
mesenchyme.
•
At E13 subsets of these cells
migrate into the submucosa.
–
This pattern is true for the
entire bowel in the mouse
and for the small intestine
in the chick.