The pancreas of DCC -/- mice is aganglionic
Neurons (PGP9.5- or acetylcholinesterase-labeled) were found in wt but not DCC-/- mice at P0 (g = gut; p = pancreas; bar = 100 µm).
Netrin/DCC play an important role in directing the migration of crest-derived cells into submucosa and pancreatic bud in vivo.
DCC -/-
wt
g
g
p
p
g
g
p
p
g
g
p
p
p
p
g
g
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p
g
g
g
g
p
p