GROWTH FACTORS IN EARLY TOOTH
DEVELOPMENT
BMP
FGF
Shh
Wnt
TNF
Bu
d
ORAL ECTODERM
ODONTOGENIC
MESENCHYME
BMP
FGF
Activin
Early signaling
center
• Sequential actions of growth factors
• Reciprocal actions of growth factors
From:  http://bite-it.helsinki.fi; Thesleff & Mikkola (2002) In Rev Cytol 217: 93-135