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Rescue
Experiment: Add
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beads soaked in
albumen or
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BMP-4.
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| 1. |
Wolffian duct
has a stem cell
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that generates
migrating
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cells. The
migration is
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‘special’-it may
involve rolling
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of cells over
each other
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creating
something like
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epiboly
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| 2. |
Migration of
cord cells and
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then their
epithelialization are
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independent.
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| 3. |
Another finding
is the
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activation of
Pax-2
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transcription in
the
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surrounding
mesenchyme.
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Pax-2 is a
transcription factor
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that is necessary for the
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next step. Note
that it is the
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epithelialized
duct that
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triggers Pax-2,
not the cord.
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