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Gruenwald in
1940 and Grobstein
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in 1953.
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What does this
experiment show?
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>Sufficiency
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>Lineage
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>Induction
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1.Nephrons come
from mesenchyme;
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Collecting ducts
come from the ureteric
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bud.
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2. The
mesenchyme is incompetent
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without the
ureteric bud or some other
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exogenous tissue.
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3. The exogenous
tissue is needed
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only 24 hours;
it throws a switch. Such
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as switch is
called ‘induction’
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4. The ureteric
bud is incompetent with
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out the
mesenchyme, ie reciprocal
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induction
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5. This is why
Boyden stopped renal
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development by
blocking the Wolffian
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duct.
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