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Mutual Dependency
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Implies that
factors made in
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Mesenchyme>>Ureteric
bud>>Mesenchyme
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Hence any
interruption of the signaling between
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these
compartments must affect both
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compartments.
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Determination of
targeting and downstream
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signaling is
complex because a factor may come
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from the
mesenchyme to instruct the ureteric
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bud to synthesize
a factor important in the
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mesenchyme.
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