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Mesenchymal
Cells into Epithelial Cells-Nephron, A Sequence
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1. Proliferation of mesenchymal cells.
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2. De novo expression of competency
factors (Pax-2, WT-1).
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3. De novo expression of conversion
factors (Wnt-4).
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4. De novo expression of junctional
proteins (NCAM>Cad6>E-cadherin>ZO-1).
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5. De novo expression of matrix proteins
(collagen I/III, Fn >laminin alpha5,
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collagen IV).
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6. De novo expression of cytoskeletal
proteins (vimentin>cytokeratin).
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Branching
Morphogenesis- Ureteric Bud, A Sequence
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1. Proliferation of epithelia
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2. Transient loss of epithelial
organizers such as E-cadherin
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3. But retention of other components of
polarity such as Zo-1
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4. Coherent growth of the tubule.
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5. Distinct populations of tip cells
which can act as pathfinders, or have different
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rates of
replication. Ret+
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6. 3 types of branching-terminal bifid,
arcade and cortical lateral-Regulatory
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events?
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