Pathophysiology of NEC
Hypertonic feedings
Overfeeding?
Hypoxia/Ischemia
Cocaine
Breast feeding
Phagocytes
Immunoglobulin
Growth factors
PAF acetylhydrolase
Bacterial Colonization
Bacterial Replication
  (+ substrate)
H2 gas Production
Cytokine production
PAF
TNF/cytokine cascade
Mucosal invasion
(endotoxin)
Pneumatosis
Sepsis/shock/SIRS
Formula feeding