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| Nicotine
and cocaine modulate |
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| self-stimulation
behavior |
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| • | In a
self-stimulation experiment, rats were permitted to apply |
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| microstimulation
to themselves at will. The rate at
which they |
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| applied
microstimulation depended upon the stimulation frequency. |
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| • | Strikingly, both
cocaine and nicotine increase behavioral response |
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| rate for a given
stimulation frequency compared to baseline.
Thus, |
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| cocaine and
nicotine appear to enhance the pleasure produced by |
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| self-stimulation. |
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| PNS Fig. 51.9 |