| Endotoxin -
Lipid A |
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| • | Essential
for Gram negative bacterial |
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| survival
and replication |
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| – | Creates
a permeability barrier for bacteria |
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| • | The
entire complex lipid A structure is |
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| necessary
for full activity |
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| • | Binds
LPS binding protein in circulation, |
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| attaches
to CD14 (receptor) on |
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| macrophage |
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| • | Triggers
cytokine pathway by activation |
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| and
direct binding of Toll receptor 4 |
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