Primary/Secondary Syphilis
Response to Treatment
• No definitive criteria for cure or failure are established
• Re-examine clinically and serologically at 6 and 12
months
• Consider treatment failure if signs/symptoms persist
or sustained 4x increase in nontreponemal test
• Treatment failure: HIV test, CSF analysis; administer
benzathine pcn weekly x 3 wks
• Additional therapy not warranted in instances when
titers don’t decline despite nl CSF and repeat therapy