 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| • |
1960s-70s: Diethylstilbesterol (DES)
|
|
|
|
– |
No longer used
because of teratogenicity
|
|
|
| • |
1974: Yuzpe
[pilot study]
|
|
|
|
– |
100 g
ethinyl estradiol (EE) with 1.0 mg dl-
|
|
|
|
norgestrel; as
effective as DES
|
|
|
| • |
1977: Yuzpe
modified (original dose given twice, 12
|
|
|
hours apart)
|
|
|
| • |
1984: Yuzpe
available in Europe
|
|