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Microbial
Pathogenicity
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Entry into host
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Find a unique niche
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Evasion, subversion or circumvention of
initial host
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defense mechanisms
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Multiplication or persistence
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Cause overt disease (optional)
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Exit the host - transmissibility
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“A key distinction is that a
pathogen has an inherent capacity
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to breach host
cell barriers, whereas a commensal species and
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opportunistic pathogens do
not.”
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Stanley Falkow’s
lecture at Columbia University 4/17/97; Falkow, S. American
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Society of Microbiology
News, 63: 539-365.
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