What is the actual genetic material, ie what is the
composition of chromosomes?
Quantitative analysis of chromosomes shows a
composition of about forty percent DNA and sixty percent
protein. At first, it seemed that protein must be responsible
for carrying hereditary information, since not only is
protein present in larger quantities than DNA, but protein
molecules are composed of twenty different subunits while
DNA molecules are composed of only four.  It seemed
clear that a protein molecule could encode not only more
information, but a greater variety of information, because it
possessed a substantially larger collection of ingredients
with which to work.