 |
|
|
|
|
|
|
|
|
|
|
| • |
Three
decades Beadle and Tatum would refine this idea
|
|
|
with
their “one gene one enzyme hypothesis”.
These
|
|
|
|
investigators
worked on Neurospora and found that if they
|
|
|
|
irradiated
spores they “induced” mutations.
These
|
|
|
|
mutations
were detected as the spores inability to
|
|
|
|
germinate
on various defined media in which essential
|
|
|
|
nutrients
were omitted. This suggested that a
mutation in a
|
|
|
specific
gene involved in the synthesis of say for instance
|
|
|
|
an
amino acid rendered the gene inactive and so no
|
|
|
|
functional
protein was made. The experiment
shown on
|
|
|
|
the next slide
exemplifies their work.
|
|