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In
1957, Matthew Meselson and Franklin Stahl did an
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experiment
to determine which of the following models
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best
represented DNA replication:
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1. Did the two strands unwind and each act
as a template
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for
new strands? This is semi-conservative replication,
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because
each new strand is half comprised of molecules
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from the old
strand.
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2. Did the strands not unwind, but somehow
generate a
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new
double stranded DNA copy of entirely new
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molecules?
This is conservative replication.
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