For other genes splicing is much more complex
	• Fibrillin is a protein that is part of connective tissue.  Mutations in it are associated with Marfan Syndrome (long limbs, crowned teeth elastic joints, heart problems and spinal column deformities. The protein is 3500 aa, and the gene is 110 kb long made up of 65 introns. • Titin has 175 introns. • With these large complex genes it is difficult to identify all of the exons and introns.