Lecture 4 mRNA splicing and protein synthesis

Adding a 5’ cap

Pre-mRNA has introns

The splicing complex recognizes semiconserved sequences

Introns are removed by a process called splicing

Splicing includes multiple proteins and small nuclear RNAs called snRNAs

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Complexity of genes

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For other genes splicing is much more complex

Alternative RNA splicing

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Gene Expression II

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How does DNA function as a code for protein synthesis?

Yanofsky precisely mapped the positions of a series of mutations in the TrpA gene

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Discovery of the genetic code

The table of codons

Central Dogma

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Assembly of ribosomes

ribosomes

Transfer RNAs (tRNAs)

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Wobble Hypothesis

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Protein synthesis

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Initiation of translation

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Termination

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Regulation of protein synthesis

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