| Termination |
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| -stop
signal on mRNA read by protein release factors causes |
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| release
of completed polypeptide chain |
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| -RF1
recognizes UAA and UAG |
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| -RF2
recognizes UAA and UGA |
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| -RF3 binds GTP and enhances action of RF1
and RF2 |
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| -binding of RF1-RF3-GTP (or RF2-RF3-GTP)
to ribosome |
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| causes hydrolysis of peptidyl-tRNA |
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| -GTP is then hydrolyzed and the release
factors dissociate |
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| from ribosome |
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