| How
Ran works |
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| • | The GEF of Ran
(denoted by RanGEF) is |
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| located
predominantly in the nucleus while |
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| RanGAP is located
almost exclusively in |
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| the
cytoplasm. Therefore, in the nucleus |
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| Ran will be
mainly in the GTP-bound |
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| state due
to the action of RanGEF while |
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| cytoplasmic
Ran will be mainly loaded |
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| with
GDP. This asymmetric distribution |
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| has led to the
following model for the |
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| function of
exportins and importins. |
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