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RanGTP
enhances binding between an exportin and
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its cargo but
stimulates release of importin's cargo;
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RanGDT has
the opposite effect, namely, it stimulates
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the release of
exportin's cargo, but enhances the binding
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between an
importin and its cargo. Therefore, the
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exportin and its
cargo may move together with RanGTP
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inside the
nucleus, but the cargo will be released as
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soon as the
complex moves into the cytoplasm (through
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nuclear pores),
since RanGTP will be converted to
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RanGDP in the
cytoplasm. By contrast, the importin and
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its cargo may
move together with RanGDP in the
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cytoplasm, but
the cargo will be released in the nucleus
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since RanGDP will
be converted to RanGTP in the
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nucleus.
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