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1. An mRNA
encoding the secretory protein
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binds to a
cytosolic ribosome.
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2. The first 70
or so amino acids are
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translated.
Since approximately 30 amino
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acids of the
protein remain buried in the
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ribosome at any
one time this leaves
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approximately 30
amino acids on the N-
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terminus of the
protein sticking out of the
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ribosome.
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These 30 amino
acids encode a signal
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sequence, which
binds with the signal
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recognition
particle or SRP in the ribosome.
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