How do proteins find their way to
the endoplasmic reticulum
1. An mRNA encoding the secretory protein
binds to a cytosolic ribosome.
2. The first 70 or so amino acids are
translated. Since approximately 30 amino
acids of the protein remain buried in the
ribosome at any one time this leaves
approximately 30 amino acids on the N-
terminus of the protein sticking out of the
ribosome.
These 30 amino acids encode a signal
sequence, which binds with the signal
recognition particle or SRP in the ribosome.