Protein modification and trafficking

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There are two types of glycosylation

Protein Glycosylation

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a-amalyase is produced in the parotid gland and is found in saliva

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How glucose gets into cells  through the action of insulin

Protein Glycosylation

Where does Dolichol come from?

Cholesterol Biosynthesis

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Dolichol

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Disulfide bonds form between cysteines

Further protein modification

Where does glucose come from?

Protein glycosylation

Now in the second step, attachment

Finally modification of oligosaccharide

Transport from the ER to Golgi

Clathrin coated vesicles

Clathrin cycle

Clathrin adaptins and dynamin

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Ubiquitin pathway for protein degradation

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Protein degradation

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