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Dolichol
is an isoprenoid compound synthesized by the
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same
metabolic route as cholesterol. In vertebrate tissues,
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dolichol
contains 18-20 isoprenoid units (90-100 carbons
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total).
Dolichol is phosphorylated by a kinase that uses
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CTP
to form dolichol Phosphate. Dolichol phosphate is
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the
structure upon which the carbohydrate moieties of N-
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linked
glycoproteins are built. After assembly on dolichol
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phosphate,
the carbohydrate structure is transferred to an
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asparagine residue of a target protein having the
sequence
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Asn-x-Ser/Thr,
where X is any amino acid.
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