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| There are endogenous and exogenous sources |
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| of
mutagens |
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| Mutagens
are any reagent that causes changes in DNA |
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| (often
referred to as DNA damage) that can ultimately |
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| lead to
a change in the DNA sequence. |
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| Examples
of endogenous reagents are; free radicals |
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| generated
during oxidation reactions, pH changes |
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| that can
lead to changes in DNA, errors in DNA |
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| replication and
recombination errors. |
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| Examples
or exogenous reagents are UV radiation, |
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| ionizing
radiation, chemicals such as benzopyrene |
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| and and
natural compounds such as aflatoxin. |
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