| DNA mismatch repair |
| 1. MutS binds to a mismatched bp |
| 2. MutS-DNA complex
binds MutL |
|
|
|
| 3. The
MutS-MutL complex |
||
| translocates
along the DNA in both |
||
| directions, forming a
loop. |
||
|
|
|
|
| 4. On
encountering a |
|||
| hemimethylated
GATC palindrome, |
|||
| the MutS-MutL
complex recrutes |
|||
| MutH |
|||