SNPs can have variable effects
		• SNPs can have no effect.  Their change can be neutral to the protein, e.g. a silent mutation. • SNPs can have a subtle effect, e.g lys to arg (both are polar basic).  This is what we suspect is happening in complex genetic diseases • SNPs can have measurable effects (a pronounced reduction in activity). • SNPs can change protein function.  A new substrate might be recognized. • SNPs can complete eliminate the proteins ability to function.