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A disease in humans known as Xeroderma Pigmentosum XP
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is a rare inherited disease of humans which, among other
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things, predisposes the patient to
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pigmented lesions on areas
of the skin exposed to the sun
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and
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an elevated incidence of
skin cancer.
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It turns out that XP can be caused by mutations in any one of
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several genes - all of which have roles to play in NER.
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James Cleaver went around and collected cells from hundreds
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of these patients. He then
figured out that the disease was
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made up of eight genes named XP-A through XP-G plus one
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called XP-V for variant.
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