| MMR cont |
|
|
|
|
|
|
|
|
| 5. MutS-MutL
recruits UvrD helicase, |
|||||||
| which in
concert with an |
|||||||
| exsonuclease,
separates the strands |
|||||||
| and
degradates the nicked strand from |
|||||||
| the nick to
beyond the mismatch. |
|||||||
| If nick is 3’
side: exsonuclease I (3’->5’ |
|||||||
| exsonulcease |
|||||||
| If nick is 5’
side: RecJ or exsonuclease |
|||||||
| VII
(5’->3’ exsonuclease) |
|||||||
|
|
| 6. DNA pol
III fills gap and DNA ligase |
|
| seals nick |
|