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The
mdm2 gene encodes a zinc finger protein that negatively regulates
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p53
function by binding and masking the p53 transcriptional activation
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domain.
Two different promoters control expression of mdm2, one of
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which
is also transactivated by p53.
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What
does negative regulation mean? MDM2
protein inhibits p53
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activity during
normal cell growth.
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How:
Inhibits p53 transcriptional activity
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Targets
p53 for ubiquitylation and degradation.
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This
inhibition is inhibited by p53 is phosphorylated.
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MDM2
has been shown to be overexpressed in sarcomas and more
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recently
was implicated in the pathogenesis of carcinomas.
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