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In 1984 two
groups reported that
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cotransfection
of murine p53 with plasmids
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encoding an
activated c-Ha-ras oncogene
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could
transform REF cells in a manner
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similar to
that observed with proto-
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oncogenes
such as myc or E1A (Eliyahu et
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al. 1984;
Jenkins et al. 1984; Parada et al.
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1984). These
observations resulted in the
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classification
of p53 as a nuclear dominant
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oncogene. A
third group, demonstrate that
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murine p53
could imortalized normal rat
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chondrocytes
leading to cells sensitive to
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ras
transformation (Jenkins et al. 1985;
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Jenkins et al.
1984).
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