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| Wild type p53 has antiproliferative |
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| properties and does not cooperate |
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| with Ha-ras |
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| • | A new set of
experiments has shown that |
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| cotransfection
of a plasmid encoding wild |
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| type p53
reduced the transformation |
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| potential of
plasmids encoding p53 and an |
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| activated
Ha-ras gene (Eliyahu et al. 1989; |
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| Finlay et al.
1989). Furthermore, wild type |
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| p53 was shown
to suppress transformation |
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| by a mixture
of E1A or myc and an activated |
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| Ha-ras gene.
These transformation |
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| experiments
indicate that wild type p53 is a |
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| suppressor of
cell transformation in vitro. |
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