| Suppression
of Oncogene |
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| To
suppress oncogene expression: |
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| • | (1)
transcriptional level: deliver a transcriptional repressor acting on the |
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| promoter
of oncogene, e.g. adenovirus E1A gene products can repress the |
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| neu
promoter or truncation protein of SV40 Large T antigen |
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| • | (2)
post-transcriptional level: deliver ribozyme, antisense, dominant |
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| negative
molecule. e. g. ribozyme for activated ras (point mutation) |
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