|
|
|
| What
cellular proteins bind E1A and SV40 Large T?? |
||
| (Harlow,
Livingston) |
||
| Objective: provide clues
into the cellular pathway. |
|
|
|
|
| What kinds of
proteins co-IP’s with E1A? |
|||
| (anti E1A IP from
35S-cells) |
|||
| RB
Family: p105, p107, p130 |
|||
| Cell
Cycle: Cyclin A, CDK2 |
|||
| For E1A and Lg.T: |
| LXCXE |
| A |
| B |
| RB |
|
|
|
| Model |
||
| E1A
neutralized RB growth arrest to enhance S-phase. |
||