| pRB Pathway |
|
|
|
| Mitogenic
Stimuli |
||
| (e.g. GF,
Ras) |
||
| RB |
| X |
| E2F |
|
|
| D-Cyclin |
|
| CDK 4/6 |
|
|
|
|
| DNA Pol |
||
| Cyclin E, p19 |
||
| DHFR, MYB |
||
| E2F |
| PPP |
|
|
| P16 |
|
| Ink4a |
|
| RB |
|
|
|
|
|
|
|
| Tumor
Suppressor Genes |
||||||
| RB, p16 |
||||||
| Oncogenes |
||||||
| Cyclin
D1 |
||||||
|
|
| From Sharpless and
DePinho (1999) |
|
| Current Opinions in Genetics and Dev. 9:22 |
|