| CARBON
DISULFIDE |
|
|
|
|
|
|
|
|
|
| • | Direct
interaction with free amine and |
|||||||
| sulfhydryl groups |
||||||||
| • | Microsomal
activation to reactive sulfur |
|||||||
| intermediates
that bind macromolecules |
||||||||
| • | Produce neuronal
degeneration in CNS; |
|||||||
| in PNS produce
myelin swelling and |
||||||||
| fragmentation |
||||||||