Center for Radiological Research
Alan W. Bigelow
Research Interests
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Contact Information
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Academic Training
- Department of Physics
- University of North Texas, Denton, Texas
- B.S. 1991, M.S. 1993, Ph.D. 2000
Current Academic Appointment
Associate Research Scientist at the Columbia University Radiological Research Accelerator Facility
Current Research
Alan Bigelow works on projects related to the single-particle single-cell microbeam irradiation system. With the current generation of the microbeam system, Alan's projects are centered on cellular dynamic imaging and on expanding the range of ion species emitted by the particle accelerator. More specifically, Alan has developed and installed a multiphoton microscope for the microbeam endstation and has built a laser ion source to be installed as an option in the terminal of the new HVE 5 MV Singletron particle accelerator at RARAF.
Publications
Some papers will be available online in PDF format. (This requires Adobe Acrobat Reader. Acrobat Reader is free and can be downloaded below). Single copies of the articles that can be downloaded and printed are for the reader's personal research and study for informational purposes only.
DNA damage foci formation and decline in two-dimensional monolayers and in three-dimensional human vessel models: Differential effects according to radiation quality, Peter Gragham, Alan Bigelow & Charles Geard, International Journal of Radiation Biology, June (2012); 88(6): 493-500.
Ion, X-Ray, UV And Neutron Microbeam Systems For Cell Irradiation, A.W. Bigelow, G. Randers-Pehrson, G. Garty, C.R. Geard, Y. Xu, A.D. Harken, G.W. Johnson, and D.J. Brenner. AIP Conf. Proc. 136, 351 (2011). [PDF]
An accelerator-based neutron microbeam system for studies of radiation effects, Yanping Xu, Gerhard Randers-Pehrson, Stephen A. Marino, Alan W. Bigelow, Mark S. Akselrod, Jeff G. Sykora, David J. Brenner, Radiat Prot Dosimetry (2011) June; 145(4): 373-376, PMCID: PMC3145382.
Expanding the question-answering potential of single-cell microbeams at RARAF, USA, Alan Bigelow, Guy Garty, Tomoo Funayama, Gerhard Randers-Pehrson, David Brenner, and Charles Geard, Journal of Radiation Research 50 A21-A28 (2009), PMCID: PMC2924733. [PDF 1,299 KB]
Microbeam-Integrated Multiphoton Imaging System, Alan W. Bigelow, Charles R. Geard, Gerhard Randers-Pehrson, and David J. Brenner, Rev. Sci. Instrum. 79 123707 (2008), PMCID: PMC2736647. [PDF 624 KB]
Single-Particle / Single-Cell Ion Microbeams as Probes of Biological Mechanisms, Alan Bigelow, David J. Brenner, Guy Garty and Gerhards Randers-Pehrson, IEEE Transactions in Plasma Science 36:1424-1431 (2008). [PDF 306 KB]
Testing the stand-alone microbeam at Columbia University, G. Garty, G. J. Ross, A. W. Bigelow, G. Randers-Pehrson, D. J. Brenner, Rad. Prot. Dos. 122 (1-4), pp. 292-296 (2006). [PDF 174 KB]
Laser Ion Source for Columbia University's Microbeam, A.W. Bigelow, G. Randers-Pehrson, R.P. Kelly and D.J. Brenner,Nucl. Instr. and Meth. in Phys. Res. B 241 (2005) 874-879. [PDF 267 KB]
A microbeam irradiator without an accelerator, G. Garty, G.J. Ross, A. Bigelow, G. Randers-Pehrson & D.J. Brenner, Nucl. Instr. & Meth in Phys. Res. B 241 (2005) 392-396. [PDF 208 KB]
Phase-based cell imaging techniques for microbeam irradiations, G.J. Ross, A.W. Bigelow, G. Randers-Pehrson, C.C. Peng, D.J. Brenner, Nucl. Instr. & Meth in Phys. Res. B 241 (2005) 387-391. [PDF 230 KB]
The Columbia University Microbeam II endstation for cell imaging and irradiation, A.W. Bigelow, G.J. Ross, G. Randers-Pehrson, and D.J. Brenner, Nucl. Instr. and Meth. in Phys. Res. B 231 (2005) 202-206. [PDF 194 KB]
Detection of chromosomal instability in alpha-irradiated band bystander human fibroblasts, B. Ponnaiya, G. Jenkins-Baker, A. Bigelow, S. Marino, and C. R. Geard, Mutation Research 568 (2004) 41-48. [PDF 111 KB]
Sample Targeting during Single-Particle Single-Cell Irradiation, A. W. Bigelow, G. Randers-Pehrson, K. A. Michel, D. J. Brenner, and A. D. Dymnikov, AIP Conference Proceedings 680 (2003) 347-350. [PDF 153 KB]
Proposed laser ion source for the Columbia University microbeam, A. W. Bigelow, G. Randers-Pehrson, and D. J. Brenner, Nucl. Instr. and Meth. in Phys. Res. B, 210 (2003) 65-69. [PDF 375 KB]
Laser Ion Source Development for the Columbia University Microbeam, Bigelow A. W., Randers-Pehrson G. and Brenner D. J., Rev. Sci. Instrum. 73, 770 (2002). [PDF 43 KB]
Measured Energy and Angular Distributions of Sputtered Neutral Atoms from a Ga:In Eutectic Alloy, A. W. Bigelow, S. L. Li, S. Matteson and D. L. Weathers, AIP Conference Proceedings 576, 108-111 (2001). [PDF 449 KB]
Sputter-Initiated Resonance Ionization Spectroscopy at the University of North Texas, A. W. Bigelow, S. L. Li, S. Matteson and D. L. Weathers, AIP Conference Proceedings 475 (1999) 569-572.
