Alan Bigelow works at RARAF which is part of the
Center for Radiological Research


Alan W. Bigelow

Research Interests
  • Ion Beam Interactions
  • Laser Interactions
  • Ion Sources
  • Optics
  • Multiphoton Microscopy
  • Raman Spectroscopy
  • Cell Growth Environment

Contact Information

Alan W. Bigelow, Ph.D.
Radiological Research Accelerator Facility
Center for Radiological Research
Nevis Laboratory, Columbia University
136 S. Broadway, Irvington, NY 10533

Tel: (914) 591-9244
Fax: (914) 591-9405
CV: LinkedIn

Academic Training

Current Academic Appointment

Associate Research Scientist at the Columbia University Radiological Research Accelerator Facility

Current Research

Alan Bigelow works on projects related to the single-particle single-cell microbeam irradiation system. With the current generation of the microbeam system, Alan's projects are centered on cellular dynamic imaging and on expanding the range of ion species emitted by the particle accelerator. More specifically, Alan has developed and installed a multiphoton microscope for the microbeam endstation and has built a laser ion source to be installed as an option in the terminal of the new HVE 5 MV Singletron particle accelerator at RARAF.


Some papers will be available online in PDF format. (This requires Adobe Acrobat Reader. Acrobat Reader is free and can be downloaded below). Single copies of the articles that can be downloaded and printed are for the reader's personal research and study for informational purposes only.

Integrated interdisciplinary training in the radiological sciences, D. J. Brenner, M. Vazquez, M. Buonanno, S. A. Amundson, A. W. Bigelow, G. Garty, A. D. Harken, T. K. Hei, S. A. Marino, B. Ponnaiya, G. Randers-Pehrson, Y. Xu, The British Journal of Radiology 87, 20130779 (2014).

207-nm UV Light - A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. I: In Vitro Studies, M. Buonanno, G. Randers-Pehrson, A. W. Bigelow, S. Trivedi, F. D. Lowy, H. M. Spotnitz, S. M. Hammer, D. J. Brenner, PLoS ONE, DOI: 10.1371/journal.pone.0076968, (2013).

Two distinct types of the inhibition of vasculogenesis by different species of charged particles, P. Grabham, P. Sharma, A. Bigelow, C. Geard, Vascular Cell 5, 16 (2013).

UV Microspot irradiator at Columbia University, A. W. Bigelow, B. Ponnaiya, K. L. Targoff and D. J. Brenner, Radiation and Environmental Biophysics 52, 411-417 (2013).

Optofluidic cell manipulation for a biological microbeam, M. Grad, A. W. Bigelow, G. Garty, D. Attinger and D. J. Brenner, Review of Scientific Instruments 84, 014301 (2013).

DNA damage foci formation and decline in two-dimensional monolayers and in three-dimensional human vessel models: Differential effects according to radiation quality, P. Grabham, A. Bigelow and C. Geard, International Journal of Radiation Biology, 88 (6): 493-500 (2012).

Ion, X-Ray, UV And Neutron Microbeam Systems For Cell Irradiation, A.W. Bigelow, G. Randers-Pehrson, G. Garty, C.R. Geard, Y. Xu, A.D. Harken, G.W. Johnson and D.J. Brenner. AIP Conf. Proc. 136, 351 (2011) PMCID: PMC3570827. [PDF]

An accelerator-based neutron microbeam system for studies of radiation effects, Y. Xu, G. Randers-Pehrson, S. A. Marino, A. W. Bigelow, M. S. Akselrod, J. G. Sykora, D. J. Brenner, Radiat Prot Dosimetry 145 (4): 373-376, (2011) PMCID: PMC3145382.

Expanding the question-answering potential of single-cell microbeams at RARAF, USA, Alan Bigelow, Guy Garty, Tomoo Funayama, Gerhard Randers-Pehrson, David Brenner and Charles Geard, Journal of Radiation Research 50 A21-A28 (2009) PMCID: PMC2924733. [PDF]

Microbeam-Integrated Multiphoton Imaging System, A. W. Bigelow, C. R. Geard, G. Randers-Pehrson and D. J. Brenner, Rev. Sci. Instrum. 79 123707 (2008) PMCID: PMC2736647. [PDF]

Single-Particle / Single-Cell Ion Microbeams as Probes of Biological Mechanisms, A. Bigelow, D. J. Brenner, G. Garty and G. Randers-Pehrson, IEEE Transactions in Plasma Science 36:1424-1431 (2008). [PDF]

Testing the stand-alone microbeam at Columbia University, G. Garty, G. J. Ross, A. W. Bigelow, G. Randers-Pehrson and D. J. Brenner, Rad. Prot. Dos. 122 (1-4), pp. 292-296 (2006). [PDF]

Laser Ion Source for Columbia University's Microbeam, A.W. Bigelow, G. Randers-Pehrson, R.P. Kelly and D.J. Brenner,Nucl. Instr. and Meth. in Phys. Res. B 241 874-879 (2005). [PDF]

A microbeam irradiator without an accelerator, G. Garty, G.J. Ross, A. Bigelow, G. Randers-Pehrson and D.J. Brenner, Nucl. Instr. & Meth in Phys. Res. B 241 392-396 (2005). [PDF]

Phase-based cell imaging techniques for microbeam irradiations, G.J. Ross, A.W. Bigelow, G. Randers-Pehrson, C.C. Peng and D.J. Brenner, Nucl. Instr. & Meth in Phys. Res. B 241 387-391 (2005). [PDF]

The Columbia University Microbeam II endstation for cell imaging and irradiation, A.W. Bigelow, G.J. Ross, G. Randers-Pehrson and D.J. Brenner, Nucl. Instr. and Meth. in Phys. Res. B 231 202-206 (2005). [PDF]

Detection of chromosomal instability in alpha-irradiated band bystander human fibroblasts, B. Ponnaiya, G. Jenkins-Baker, A. Bigelow, S. Marino and C. R. Geard, Mutation Research 568 41-48 (2004). [PDF]

Sample Targeting during Single-Particle Single-Cell Irradiation, A. W. Bigelow, G. Randers-Pehrson, K. A. Michel, D. J. Brenner and A. D. Dymnikov, AIP Conference Proceedings 680 347-350 (2003). [PDF]

Proposed laser ion source for the Columbia University microbeam, A. W. Bigelow, G. Randers-Pehrson and D. J. Brenner, Nucl. Instr. and Meth. in Phys. Res. B, 210 65-69 (2003). [PDF]

Laser Ion Source Development for the Columbia University Microbeam, A. W. Bigelow, G. Randers-Pehrson and D. J. Brenner, Rev. Sci. Instrum. 73, 770 (2002). [PDF]

Measured Energy and Angular Distributions of Sputtered Neutral Atoms from a Ga:In Eutectic Alloy, A. W. Bigelow, S. L. Li, S. Matteson and D. L. Weathers, AIP Conference Proceedings 576, 108-111 (2001). [PDF]

Sputter-Initiated Resonance Ionization Spectroscopy at the University of North Texas, A. W. Bigelow, S. L. Li, S. Matteson and D. L. Weathers, AIP Conference Proceedings 475 569-572 (1999).