The Department of Biomedical Informatics (DBMI) of Columbia University seeks researchers interested in applying modeling and computational sciences to medicine, biology, and public health. There is particular interest in machine learning, multiscale modeling, and network analysis. DBMI (www.dbmi.columbia.edu) comprises 32 faculty members and 61 students. The department has amassed a large, diverse research portfolio, breaking new ground in several areas of informatics research. The Department's mission is to improve the health of the population and to make biomedical discoveries using information and computational techniques. The Department runs a 2.5-million-patient 18-year electronic health record that is used by 7000 health care providers. It participates in a $30 million project with the New York City Department of Health and Mental Hygiene to deploy electronic health records across the city, with the hope of using the system to improve the health of the population and to carry out health department functions such as syndromic surveillance. The Department is known for its work on medical language processing, decision making and cognition, and systems biology. Potential projects include the following: modeling the spread of infection across a population; modeling the progression of a chronic disease, including predicting and intervening on exacerbations (e.g., for asthma); modeling social behavior among health care participants to improve workflow; and developing a model for temporal uncertainty of disease signs and symptoms. In many cases, the Department has access to relevant large databases from which an empirical distribution can be developed, a training set can be extracted, and simulation can be tested. The ideal candidate will have a strong record of accomplishments and publications in research areas spanning the boundary between life sciences and the computational sciences. The candidate must have a doctorate in Biomedical Informatics, Computer Science, Physics, or a related field. Positions are available in the tenure track. Level of appointment will be commensurate with experience. If you seek a challenging research career in a highly collaborative, multidisciplinary department, please send a two-page description of your interest, a curriculum vitae, a set of no more than 10 relevant publications, and the names of at least three referees to George Hripcsak, MD, MS, Department of Biomedical Informatics, VC5, 622 West 168th Street, New York, NY 10032 (hripcsak@columbia.edu). Columbia University is an equal opportunity and affirmative action employer.