Protein folding, assembly, and intracellular protein trafficking

 

Miller Lab

Research in the Miller lab is broadly aimed at understanding the rules that govern uptake of cargo proteins into transport vesicles, a process that is influenced by the presentation of sorting signals, by the folding state of the client protein and by the vesicle coat itself.


We use the budding yeast, Saccharomyces cerevisiae, as a model system. Three main research arms of the Miller lab attack this problem from different angles: we probe the molecular functions of the coat protein, Sec24p; we study the client proteins that must navigate the quality control checkpoint; and we are developing tools to examine the role of the hydrophobic lipid environment in protein folding, cargo selection and vesicle formation.