WORMAN LAB

Welcome to the WWW Home Page of the Worman Lab

Howard J. Worman, M. D.
Departments of Medicine and of Anatomy and Cell Biology
Columbia University College of Physicians & Surgeons
New York, New York

Email: hjw14@columbia.edu

CURRENT LAB MEMBERS

RESEARCH ACTIVITES

SELECTED RECENT PUBLICATIONS

Wang, Y., Panteleyev, A. A., Owens, D. M., Djabali, K. Stewart, C. L. and Worman, H. J. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. Hum. Mol. Genet. 2008;17:2357-2369.

Muchir, A., Shan, J., Bonne, G., Lehnart, S. E. and Worman, H. J. Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins. Hum. Mol. Genet. 2009;18:241-247.

Ostlund, C., Folker, E. S., Choi, J. C., Gomes, E. R., Gundersen, G. G. and Worman, H. J. Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J. Cell Sci. 2009;122:4099-4108

Wu, W., Shan, J., Bonne, G., Worman, H. J. and Muchir, A. Pharmacological inhibition of c- Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene. Biochim. Biophys. Acta 2010;1802:632-638.

Wang, Y., Ostlund, C. and Worman, H. J. Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome. Nucleus 2010;1:432-439.

Kond, E., Bourgeois, B., Tellier-Lebegue, C., Wu, W., Prez, J., Caputo, S. M., Attanda, W., Gasparini, S., Charbonnier, J. B., Gilquin, B., Worman, H. J. and Zinn-Justin, S. Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-beta signaling at the inner nuclear membrane. Biochemistry 2010;49:8020-8032.

Folker, E. S., Ostlund, C., Luxton, G. W. G., Worman, H. J. and Gundersen, G. G. Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement. Proc. Natl. Acad. Sci. USA 2011;in press.

Wu, W., Muchir, A., Shan, J., Bonne, G and Worman, H. J. Mitogen activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by lamin A/C gene mutation. Circulation 2011;in press.

SUPPORTED OVER THE YEARS BY

USEFUL LINKS

LOCAL LINKS

WORMAN LAB/Columbia University College of Physicians & Surgeons/hjw14@columbia.edu