Iuliana Ionita-Laza Assistant Professor Department of Biostatistics Columbia University

• Iuliana Ionita-Laza, Vlad Makarov, Joseph Buxbaum, the AASC "Scan-statistic approach identifies clusters of rare disease variants in three independent datasets in LRP2, a gene linked and associated with autism spectrum disorders", American Journal of Human Genetics, in press, 2012


• Iuliana Ionita-Laza, Michael Cho, Nan Laird "Statistical challenges in sequence-based association studies with population- and family-based designs", Statistics in Biosciences, 2012 (invited article)


• Iuliana Ionita-Laza, Vlad Makarov, Seungtai Yoon, Benjamin Raby, Joseph Buxbaum, Dan Nicolae, Xihong Lin "Finding genes in Mendelian disorders using sequence data: methods and applications" American Journal of Human Genetics, 2011, Source Code, Simulated Example (highlighted in Nature Genetics)


• Iuliana Ionita-Laza and Ruth Ottman "Design of association studies with rare variants" Genetics, 2011, Source Code (EPV), and Source Code (Power), and Documentation


• Iuliana Ionita-Laza, Joseph Buxbaum, Nan Laird and Christoph Lange "A new testing strategy to identify rare variants with either risk or protective effect on disease" Plos Genetics, 2011 -- Source Code and Documentation


• Iuliana Ionita-Laza, Nan Laird "On the optimal design of genetic variant discovery studies" Statistical Applications in Genetics and Molecular Biology, 2010


• Iuliana Ionita-Laza, Christoph Lange, Nan Laird "On a method to count the number of unseen variants in the human genome" Proceedings of the National Academy of Sciences 2009 (story)


• Iuliana Ionita-Laza, Nan Laird, Benjamin Raby, Scott Weiss, Christoph Lange "On the frequency of copy number variants" Bioinformatics 2008


• Iuliana Ionita-Laza, Matthew McQueen, Nan Laird, Christoph Lange "Genomewide Weighted Hypothesis Testing in Family-Based Association Studies, with an Application to a 100K Scan" American Journal of Human Genetics 2007


• Iuliana Ionita, Raul-Sam Daruwala, Bud Mishra "Mapping Tumor Suppressor Genes using Multipoint Statistics from Copy-Number Variation Data" American Journal of Human Genetics 2006

I am the principal investigator on the following grants:

- NIH-R01 (MH095797, 2012-2016)
- NSF (DMS-1100279, 2011-2014)
- NIH-R03 (HG005908, 2010-2013)

I am an associate editor for Biometrics, and am also a review editor for Frontiers in statistical genetics and methodology.

- UCLA Workshop on Mathematical and Computational Approaches in High-Throughput Genomics, December 2011
- I am organizing an invited session on "Methodological challenges in high-dimensional genetic data" at JSM 2012
- I am on the organizing committee for the Harvard PQG conference in 2012
- I am giving a talk at ICSA 2012

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