Department of Biostatistics
Research Statistical genetics. My main research interests lie at the interface between statistics and genetics. I am particularly interested in developing statistical and computational methods for the analysis of high-dimensional genetic data, such as generated by next-generation sequencing technologies. I am also involved in applications of such methods to psychiatric diseases, including autism spectrum disorders and schizophrenia. Below is a list of recent and selected publications.
- Iuliana Ionita-Laza, Bin Xu, V Makarov, Joseph Buxbaum, J. Louw Roos, Joseph Gogos, Maria Karayiorgou, "A Scan-Statistic Based Analysis of Exome Sequencing Data Identifies FAN1 at 15q13.3 as a Susceptibility Gene for Schizophrenia and Autism", Proceedings of the National Academy of Sciences USA, in press, 2013
- Iuliana Ionita-Laza, Seunggeun Lee, Vlad Makarov, Joseph Buxbaum, Xihong Lin "Sequence kernel association tests for the combined effect of rare and common variants", American Journal of Human Genetics, 2013, Software, (brief SFARI story)
- Bin Xu, Iuliana Ionita-Laza, J Louw Roos, Braden Boone, Scarlet Woodrick, Yan Sun, Shawn Levy, Joseph A Gogos, Maria Karayiorgou "De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia", Nature Genetics, 2012
- Iuliana Ionita-Laza, Seunggeun Lee, Vlad Makarov, Joseph Buxbaum, Xihong Lin "General class of family-based association tests for sequence data, and comparisons with population-based association tests", European Journal of Human Genetics, 2013, Source Code
- Iuliana Ionita-Laza, Vlad Makarov, the AASC, Joseph Buxbaum "Scan-statistic approach identifies clusters of rare disease variants in three independent datasets in LRP2, a gene linked and associated with autism spectrum disorders", American Journal of Human Genetics, in press, 2012 (SFARI news story)
- Iuliana Ionita-Laza, Michael Cho, Nan Laird "Statistical challenges in sequence-based association studies with population- and family-based designs", Statistics in Biosciences, 2012 (invited article)
- Iuliana Ionita-Laza, Vlad Makarov, Seungtai Yoon, Benjamin Raby, Joseph Buxbaum, Dan Nicolae, Xihong Lin "Finding genes in Mendelian disorders using sequence data: methods and applications" American Journal of Human Genetics, 2011, Source Code, Simulated Example (highlighted in Nature Genetics)
- Iuliana Ionita-Laza and Ruth Ottman "Design of association studies with rare variants" Genetics, 2011, Source Code (EPV), and Source Code (Power), and Documentation
- Iuliana Ionita-Laza, Joseph Buxbaum, Nan Laird and Christoph Lange "A new testing strategy to identify rare variants with either risk or protective effect on disease" Plos Genetics, 2011 -- Source Code and Documentation
- Iuliana Ionita-Laza, Angela Rogers, Christoph Lange, Benjamin Raby, Charles Lee "Genetic association analysis of copy number variation in human disease pathogenesis" Genomics 2009
- Iuliana Ionita-Laza, Nan Laird "On the optimal design of genetic variant discovery studies" Statistical Applications in Genetics and Molecular Biology, 2010
- Iuliana Ionita-Laza, Christoph Lange, Nan Laird "On a method to count the number of unseen variants in the human genome" Proceedings of the National Academy of Sciences 2009 (story)
- Iuliana Ionita-Laza, Nan Laird, Benjamin Raby, Scott Weiss, Christoph Lange "On the frequency of copy number variants" Bioinformatics 2008
- Iuliana Ionita-Laza, Matthew McQueen, Nan Laird, Christoph Lange "Genomewide Weighted Hypothesis Testing in Family-Based Association Studies, with an Application to a 100K Scan" American Journal of Human Genetics 2007
- Iuliana Ionita, Raul-Sam Daruwala, Bud Mishra "Mapping Tumor Suppressor Genes using Multipoint Statistics from Copy-Number Variation Data" American Journal of Human Genetics 2006
I am the principal investigator of the following grants:
- NIH-R01 (MH095797, 2012-2016)
Some professional activities
- NSF (DMS-1100279, 2011-2014)
- NIH-R03 (HG005908, 2010-2013)
I am an associate editor for Biometrics, and a review editor for Frontiers in statistical genetics and methodology.
Recent selected conferences I have been involved with: IPAM, UCLA Workshop, Harvard PQG (November 2012), ENAR (March 2013), MAGES (UPenn, May 2013), Lipari Summer School (July 2013), JSM (August 2013), MSKCC Workshop (August 2013), Banff Statistical Genetics Workshop (June 2014), JSM (August 2014)
Seminars of interest at Columbia University: Gotham Seminar on Genomics and Statistics, Genetic Epidemiology Seminar, Biostatistics Colloquium
Institute for Data Sciences and Engineering
Research Positions A postdoctoral position in statistical/quantitative genetics is available in my group. For information please email me at email@example.com. Also, graduate students interested in working in statistical genetics are encouraged to contact me.
722 W 168th Street, 6th Fl, Rm 646
New York, NY 10032
Office Phone: 212-305-9645
Some Personal Links I spend most of my free time with my daughter Irina Maia. She is ~16 months now, and very very cute. We have lots of children books at home, and she likes to look, and leaf through them, and have us read them to her, sometimes over and over again.
Radu, Random Photos