Igor Shuryak works in the Center for Radiological Research

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Igor Shuryak, M.D., Ph.D.

 
  Research Interests

1. Biologically-motivated quantitative mathematical modeling of radiation effects including:

  • The mechanisms of carcinogenesis induced by radiation, both at low doses for environmental
    concerns, and at high doses related to radiotherapy
  • Bystander effects
  • Inverse dose rate effects
  • Oxidative stress
  • DNA repair
  • Cell death
2. Testing theoretical concepts of radiation carcinogenesis using experimental animals:
  • In 2011-2012 Dr. Shuryak served as PI of a study on radiation-induced mammary
    carcinogenesis in mice funded by a Pilot Study Award from the Irving Institute for Clinical and Translational Research and The Clinical Trials Office

Contact Information

Igor Shuryak
Center for Radiological Research
Columbia University
630 W. 168th St.
VC 11-234/35
New York, NY 10032

Tel: (212) 305-2405
Fax: (212) 305-3229
Email: is144@columbia.edu

  

Education

Academic and Professional appointments

2010 - Associate Research Scientist, Center for Radiological Research, College of Physicians & Surgeons of Columbia University
2006-2009 Postdoctoral Fellow, Cancer Training Program, Department of Epidemiology of Columbia University
2001-2005 Student Researcher, Department of Radiation Oncology, SUNY Downstate Medical Center

Awards

Grants

  • Pilot Study Award grant from the Irving Institute for Clinical and Translational Research, Low Dose Prophylactic Mammary Irradiation to Reduce Contralateral Second Breast Cancer Risks, 2011-2012

  • 2U19AI067773-06 (PI: Brenner, D.J.), NIAID, Center for High-throughput Minimally-Invasive Radiation Biodosimetry

Curriculum Vitae

Click here to download a full CV.

Publications

Single copies of the articles can be downloaded and printed for the reader's personal research and studied for informational purposes only.

  1. Shuryak I, Brenner DJ.Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death. Radiat Res. 2012 Jul;178(1):17-24. Abstract, Full Text

  2. Ng J, Shuryak I, Xu Y, Clifford Chao KS, Brenner DJ, Burri RJ.Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapy. Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1101-6. Abstract, Full Text

  3. Shuryak I, Brenner DJ, Ullrich RL. Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA. PLoS One. 2011;6(12):e28559. Abstract, Full Text

  4. Brenner DJ, Shuryak I. Ten Years of Follow-Up Is Not Long Enough to Assess Lifetime Cancer Risks Caused by Computed Tomography Scans in a Young Population. J Clin Oncol. 2011 Oct 20;29(30):4062 Abstract, Full Text

  5. Brenner DJ, Shuryak I, Einstein AJ. Impact of Reduced Patient Life Expectancy on Potential Cancer Risks from Radiologic Imaging. Radiology. 2011. Jul 19. [Epub ahead of print]. Abstract, Full Text

  6. Turner HC, Brenner DJ, Chen Y, Bertucci A, Zhang J, Wang H, Lyulko OV, Xu Y, Shuryak I, Schaefer J, Simaan N, Randers-Pehrson G, Yao YL, Amundson SA, Garty G. Adapting the γ-H2AX assay for Automated Processing in Human Lymphocytes. 1. Technological Aspects. Radiat Res. 2011 Mar;175(3):282-90. Abstract, Full Text

  7. Shuryak I, Sachs RK, Brenner DJ. A new view of radiation-induced cancer. Radiat Prot Dosimetry. 2011 Feb;143(2-4):358-64. Abstract, Full Text

  8. Shuryak I, Sachs RK, Brenner DJ. Cancer risks after radiation exposure in middle age. J Natl Cancer Inst. 2010 Nov 3;102(21):1628-36. Abstract, Full Text

  9. Shuryak I, Ullrich RL, Sachs RK, Brenner DJ. The balance between initiation and promotion in radiation-induced murine carcinogenesis. Radiat Res. 2010 Sep;174(3):357-66. Abstract, Full Text

  10. Shuryak I, Brenner DJ. Effects of radiation quality on interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. Radiat Environ Biophys. 2010 Nov;49(4):693-703. Abstract, Full Text

  11. Shuryak I, Brenner DJ. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J Theor Biol. 2009 Nov 21;261(2):305-17. Abstract, Full Text

  12. Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: Approach. Radiat Environ Biophys. 2009 Aug;48(3):263-74. Abstract, Full Text

  13. Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys. 2009 Aug;48(3):275-86. Abstract, Full Text

  14. Brenner DJ, Shuryak I. Prospective Second-Cancer Risk Estimation for Contemporary Radiotherapeutic Protocols. Book chapter in: Cancer survivorship research and education, late effects on normal tissues, eds. P. Rubin, L.S. Constine, L.B. Marks, P. Okunieff. Springer Verlag, 2008.

  15. Shuryak I, Sachs RK, Brenner DJ. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res. 2007 Dec;168(6):741-9. Abstract, Full Text

  16. Brenner DJ, Shuryak I, Russo S, Sachs RK. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J Clin Oncol. 2007 Nov 1;25(31):4868-72. Abstract, Full Text

  17. Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol. 2007 Dec 7;249(3):518-31. Abstract, Full Text

  18. Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks. J Natl Cancer Inst. 2006 Dec 20;98(24):1794-806. Abstract, Full Text

Directions

Take the A, C, or 1 subway train to West 168th Street. From the corner of 168th Street and Broadway, walk 1/2 block west along 168th Street to 630 West 168th Street (College of Physicians and Surgeons).

Check in with the guard, tell them you are visiting Igor Shuryak (internal phone 5-2405). Get a pass, take the elevators up to the 11th floor. You'll be faced with a long corridor. Turn left at the corridor, walk all the way to the end, and stop at VC 11-234/35 (on the left).

 


Click on the map above for an interactive map of the area.

Igor Shuryak
Center for Radiological Research
VC 11-234/35
630 W. 168th St.
New York, NY 10032

The map was provided by Mapquest.

This page was last updated September 24, 2011.