JOHN D. LOIKE, PH.D.
179-20 Tudor Road
Jamaica Estates, New York 11432
1976 Ph.D. Albert Einstein College of Medicine Department of Molecular Pharmacology. Dr. Susan B. Horwitz
1971 B.A. Yeshiva University- Major: Biology ACADEMIC APPOINTMENTS AND TEACHING
2007-Present Director of Special Programs, Center for Bioethics, Columbia University
2010-Present Faculty Affiliate, Masters in Bioethics Program, Columbia University
2013-Present Co-director for International Consortium on the relationship between science and and religion
2013-2014 Course Director for Healthcare Management, Fordham School of Business
2007-Present Course Director for Frontiers in Bioethics in collaboration with Mahidol University, Bangkok, Thailand
2011-2013 Course Director for Stem Cell Biology, Ethics, and Applications, Columbiaa ia College
2008-Present Course co-Director- Pathophysiology of Cardiovascular System-Graduate level
2007-Present Course Director for Ethics for Biomedical Engineers, Biomedical Engineering, Columbia College
2007-Present Creator and Director of BioEthical Crosscultural Education Program (BioCEP)
2004-present Co-Director of Graduate Studies, Department of Physiology, Columbia University College of Physicians and Surgeons
2003-Present Creator and Faculty editor of Columbia University Journal of Bioethics
2000- Present Advisory Board, Columbia University Center for the Study of Science and Religion
2002-Present Course Director for Crossroads in Bioethics, Columbia College
1990-Present Research Scientist, Columbia University College of Physicians and Surgeons, Department of Physiology
1984-1989 Associate Research Scientist, Columbia University College of Physicians and Surgeons, Department of Physiology
1980-1984 Research Associate, The Rockefeller University Department of Cellular Physiology and Immunology
1977-1980 Postdoctoral Fellow, The Rockefeller University, Department of Cellular Physiology & Immunology
1976-1977 Damon Runyon-Walter Winchell Cancer Fund Fellow
The Rockefeller University, Department of Cellular Physiology and Immunology PROFESSIONAL SOCIETIES
New York Academy of Sciences
American Association for the Advancement of Science
American Society for Cell Biology
Cardiovascular Research Initiative (CVRI) of Columbia University CURRENT GRANTS
Department of Defense- 2008-2014
National Science Foundation Grant with Metropolitan Museum of New York 2011-2014
Picower Foundation 2009-2014 HONORS AND AWARDS
1971 Who's Who in American Colleges and Universities
1976-1977 Damon Runyon-Walter Winchell Cancer Fund Fellow
1977-1980 National Institutes of Health-Postdoctoral Fellow
1980-1982 Grant Recipient - National Science Foundation
1980-1983 Grant Recipient- Muscular Dystrophy Association
1982-1986 Grant Recipient - National Institutes of Health
1985-1986 Research Development Award- Muscular Dystrophy Association
1988-1993 Grant Recipient - National Institutes of Health
1990-1992 Grant Recipient- Juvenile Diabetes Foundation
1996-1997 Bristol-Myers Research Grant
2002-2003 Merck Research Grant
2007 Revel Award for Professional Development in Arts and Sciences
2008-2012 Department of Defense Grant
2009-2010 Grant from Nanovibronix
2010-2012 Grant from New York State NYSTEM
2010 Finalist for Columbia University’s Presidential Teaching Award
2012-2014 Grant from National Science Foundation
2011-2014 Grant from Picower Foundation on Parkinson’s Disease Advisory Board for Summer Research Program for Science Teachers
Supervised high school science teachers for summer research programs in my laboratory. 1991-2000 Journal Reviewer for:
Journal of Experimental Medicine,
Journal of Immunology,
Journal of Leukocyte Biology,
Kennedy Institute of Ethics Journal
Journal of Motor Neuron Grant Reviewer
Alzheimer's Association National Science Foundation
BusinessWeek, 2006 BusinessWeek video, 2006 NBC weekend news, 2007
SCIENTIFIC RESEARCH FOCUS
- Regulation of the immune system in response to Alzheimer’s disease, cancer, and inflammation. We have published new innovative data to enhance the immune response to eradicate cancers such as melanoma.
- We are also examining the role of inflammatory cells in chronic diseases such as Parkinson’s disease.
- We have develop new diagnostic technology that we believe can help identify and treat individuals who have been exposed to sub-lethal doses of radiation from a nuclear accident or bioterrorist event.
- In collaboration with the Metropolitan Museum of New York, we have developed new immunological techniques to assess the source materials of proteins and polysaccharides in artworks.
- In collaboration with NanoVibronix, we are examining ways to combat bacterial infections that are common in patients that have prosthetic devices or urinary tract catheters.
- Developing online learning course “Stem Cell Science, Ethics, and Applications.
- Mentoring undergraduate students who have done research in the laboratory. All of these students have continued their education in either M.D. or M.D./Ph.D. programs at top universities.
- Serving on the advisory board of Columbia’s Summer Research Program for Secondary School Science Teachers. Through this teacher development program thousands of students have improved their performance on Regents exams. Five teachers have rotated in the laboratory.
- Created two innovative undergraduate courses. The first is Cross-roads in Bioethics where each spring about 20 students are taught to develop strategies to meet the new bioethical challenges emerging from new biotechnologies. This is an interactive course based on the principle that good bioethics comes from a clear understanding of the underlying science. The second course is Ethics for Biomedical Engineers where students are exposed to current topics of bioethics related to engineers such as “Do cell phones present a tumor risk to users” or “Can brain imaging predict human behavior”. These are highly popular courses where students not only learn about science-based bioethics but develop methodologies to enhance creativity and writing skills.
- Speaking to lay audiences around the country including religious groups and student clubs at both Columbia and other universities such as NYU, Touro College, Albert Einstein College of Medicine, and Columbia’s Café-Social Science.
- Created the Columbia University Journal of Bioethics speaks as a first-class journal where Columbia University students can express their views on emerging bioethical issues.
- Created and directs Bioethic Cross-cultural Education Program (BioCEP). In its fourth year, BioCEP has emerged as a leading internship prototype for interscholastic cooperation designed to expose and align international students with multidisciplinary modern global issues in the areas of bioethics and medical ethics. BioCEP is a rigorous educational enrichment summer workshop where students from American and Southeast Asian universities spend two weeks in Thailand engaged in lectures, discussions, and on-site professional visits to learn how government policies, culture, and religion impact bioethical and medical ethical issues.
1. Loike, J.D.
and Horwitz, S.B. The Effects of Podophyllotoxin and VP-16-213 on Microtubule Assembly `in vitro' and Nucleoside Transport in HeLa Cells. Biochem. 15
, 5435-5442, 1976.
2. Loike, J.D.
and Horwitz, S.B. The Effect of VP-16-213 on the Intracellualar Degradation of DNA in HeLa Cells. Biochem. 15
, 5443- 5448, 1976.
3. Horwitz, S.B. and Loike, J.D.
A Comparison of the Mechanism of Action of VP-16-213 and Podophyllotoxin. Lloydia 40
, 82-88, 1977.
4. Loike, J.D.
, Brewer, C.F., Sternlicht, H., Gensler, W.J. and Horwitz, S.B. Structure-Activity Study of the Inhibition of Microtubule Assembly in vitro' by Podophyllotoxin and its Congeners. Cancer Res. 38
, 2688- 2693, 1978.
5. Brewer, C.F., Loike, J.D.
, Horwitz, S.B., Sternlicht, H. and Gensler, W.J. Conformational Analysis of Podophyllotoxin and its Congeners. Structure-Activity Relationship in Microtubule Assembly. J. Med. Chem. 22
, 215-221, 1979.
6. Loike, J.D.
, Kozler, V.F. and Silverstein, S.C. Increased ATP and Creatine Phosphate Turnover in Phagocytosing Mouse Peritoneal Macrophages. J. Biol. Chem. 254
, 9558-9564, 1979.
7. Silverstein, S.C. and Loike, J.D.
Phagocytosis. In: Mononuclear Phagocytes (R. van Furth and Z.A. Cohn, eds.). Nignhof, Amsterdam pp. 895-917, 1980.
8. Silverstein, S.C., Michl, J. and Loike, J.D.
Studies on the Mechanisms of Phagocytosis. Symposium papers of the 2nd International Conference on Cell Biology, pp.602-622, 1980.
9. Loike, J.D.
, Silverstein, S.C. and Sturtevant, J. M. Application of Differential Scanning Microcalorimetry to the Study of Cellular Processes. I. Heat Production and Glucose Oxidation of Murine Macrophages. Proc. Natl. Acad. Sci. 78
, 5958-5962, 1981.
10. Loike, J.D.
VP-16-213 and Podophyllotoxin; A Study on the Relationship Between chemical Structure and Biological Activity. Can. Chemother. Pharmacol. 7
11. Loike, J.D.
and Silverstein, S.C. A Fluorescent Quenching Technique using Trypan Blue to Differentiate Between Attached and Ingested Glutaraldehyde-fixed Red Blood Cells in Phagocytosing Macrophages. J. of Immunol. Methods. 57
, 373-379, 1983.
12. Loike, J.D.
VP-16-213 and Podophyllotoxin. A Review of their Different Mechanisms of Action. Trends in Pharmacological Sciences. 5
, 30-33 1984.
13. Loike, J.D.
, Kozler, V.F. and Silverstein, S.C. Creatine Kinase Expression and Creatine Phosphate Accumulation are Developmentally Regulated During Differentiation of Human and Mouse Monocytes. J. Exp. Med. 159
, 746-757, 1984.
14. Loike, J.D.
, M. Somes, & S.C. Silverstein. Creatine uptake, metabolism, and efflux in human monocytes and macrophages. Am. J. Physiol. 251
(Pt 1)P C128-35 1986.
15. Loike, J.D.
, D.L. Zalutsky, E. Kaback, A.F. Miranda, S.C. Silverstein. Extracellular Creatine Regulates Creatine Transport in Rat and Human Muscle Cells. Proc. Natl. Acad. Sci. 85
, 807-811, 1988.
16. Hoffman, E.P., K. Fischbeck, R.H. Brown, M. Johnson, R. Medori, J. Loike
, J.B. Harris, R. Waterston, M. Brook, L. Specht, R. Kupsky, J. Chamberlain, C. T. Caskey, F. Shapiro and L.M. Kunkel. Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne's or Becker's muscular dystrophy. New Eng. J. Med. 318
, 1363-1368, 1988.
17. Wright, S.D., J.I. Weitz, A.J. Huang, S.M. Levin, S.C. Silverstein and J. D. Loike
. Complement receptor type three (CR3, CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc. Natl. Acad. Sci. 85,
18. Fischbarg, J., Kuang, K., Hirsch, J., Lecuona, S., Rogozinski, L, Silverstein, S.C., & Loike, J.D.
Evidence that the glucose transporter serves as a water channel in J774 macrophages. Proc. Natl. Acad. Sci. 86,
19. Fischbarg, J., Kuang, K., Vera, J.C., Arant, S. Silverstein, S.C., Loike, J.D.
and Rosen, O.M. Glucose transporters serve as water channels. Proc. Natl. Acad. Sci. 87
, 3244-3247, 1990.
20. Loike, J.D.
Biological and clinical properties of podophyllotoxin and other lignans, in Lignans: Chemical, biological and clinical properties. Cambridge Press (Ayres & Loike
, Eds) 1990.
21. Loike, J.D.
Etoposide and teniposide, in Lignans: Chemical, biological and clinical properties. Cambridge Press (Ayres & Loike
, Eds) 1990.
22. Loike, J.D.
, Sodek, B., Lecuona, S., Weitz, J., Detmers, P.A., Wright, S.W., & Silverstein, S.C. CDc/CD18 on Neutrophils is a receptor for fibrinogen. Proc. Natl. Acad. Sci, 88:11044-1048, 1991.
23. Loike, J.D.
From genes to dreams-ethical issues of molecular medicine. 1991. Monograph; Association of Orthodox Jewish Scientists.
24. Loike, J.D.
, Brett, J., Ogawa, S., Silverstein, S.C. and Stern, D. Hypoxia and inhibition of oxidative phosphorylation induce glucose transporter expression in cultured endothelial cells. American J Physiology, 263:c326-c333, 1992.
25. Loike, J.D.
, R. Silverstein, S.D. Wright, J.I. Weitz and S. C. Silverstein.The role of protected extracellular compartments in interactions between leukocytes, and platelets and fibrin/fibrinogen matrices. in Plasminogen activation in fibrinoglysis, in tissue remodeling, and in development. Brakman, P., and Kluft, C., (Editors) Ann. N.Y. Acad. Sci. 667:163-177, 1992.
26. Fischbarg, J., K. Kuang, J. Li, S. Arant-Hickman, J.C. Vera, S.C. Silverstein, J.D. Loike
. Facilitative and sodium dependent glucose transporters behave as water channels. Isotonic tansport in leaky epithelia. Alfred Benzon Symposium 34:432-446, 1993
, R. Silverstein, L. Cao, L. Solomon, J.Weitz, E. Haber, G.R. Matsueda, M.S. Bernatowicz, and S.C. Silverstein. Activated platelets form protected compartments with fibrinogen and fibronectin-coated surfaces. J. Cell Biol. 121:945-955, 1993.
28. Loike, J.D.
, Kaback, E., Silverstein, S.C. and Steinberg, T.S. pH-dependent lactate transport in macrophages. J. Immul. 150:1-8, 1993.
29. Loike, J.D
., M, Cao, L., Silverstein, S.C., Vera, J.C., and Fischbarg, J. Inhibitors of glucose transport reduce diffusional water permeability through J774 cells. J. Gen. Physiol. 102:1-10, 1993.
30. Silverstein, S.C. and Loike, J.D.
Public needs to learn of NIH's role in university research. FASEB Newsletter (June/July 1993).
31. Silverstein, S.C. and Loike, J.D.
Scientists must educate the public that NIH is the principal federal agency that supports biomedical research. FASEB J. 7:1309, 1993.
32. Silverstein, S.C., Fitch, F.W., and Loike, J.D.
Scientists Should Make Sure They Give NIH Proper Credit For Funding Their Research. The Scientist 7:12, Nov. 15, 1993.
33. Hoffman, S. Dutton, S.L., Ernst, H., Boackle, M.K., Everman, D., Tourkin, A., and Loike, J.D.,
Functional characterization of anti-adhesion molecules. Perspectives in Development Neurbiology 2:101-110, 1994.
34. El Khoury, J., J. Loike,
L. Cao, C. Thomas, and S.C. Silverstein. Macrophages adhere to glucose-modified fibronectin and collagen IV via their scavenger receptors. J. Biol. Chem. 269:10197-10200. 1994.
35. Loike, J.D.
, Richards, C.P., Manderville, J., Maxfield, F., El Khoury, J., Cao, L., and Silverstein, S.C. Fibrin regulates neutrophil migration in response to interleukin 8 and LTB4, TNF or fMLP. J. Exp. Med 181:1763-1772.1995
36. El Khoury, J., S. E. Hickman, C. A. Thomas, L. Cao, S.C.Silverstein, and J. D. Loike
. Scavenger receptor-mediated adhesion of microglia to -amyloid fibrils and secretion of reactive oxygen species. Nature 382:716-719. 1996.
S.A. Hickman, K. K. Ming Xu, L. Cao, J. C. Vera, S. C. Silverstein, and J.Fischbarg. Sodium/glucose cotransporters display sodium and phlorizin-dependent water permeability. Amer. J. Physiol. 271:c1774-1779, 1996.
38. Benimestskaya, L., Loike, J.D.
, Khaled, Z. Loike, G., Silverstein, S.C., Cao, L., El-Khoury, J., Cai, T. and Stein, C.A. Mac-1 (CD11b/CD18) is an oligodexoynucleotide binding protein. Nature Medicine, 3:414-420, 1997.
39. Yin, B., Loike, J.D.
Weinstock, P.H., Breslow, J.L., Silverstein, S.C.,, and Goldberg, I.J. Lipoprotein Lipase regulates metabolic energy in phagocytosing macropahges during hypoglycemia. J. Clincial Investigation 100: 649-657, 1997.
40. El Khoury, J., S. E. Hickman, C.A. Thomas, J.D. Loike
and S.C. Silverstein. Microglia, scavenger receptors, and the pathogenesis of Alzheimer’s disease. Neurobiology of Aging. 19:581-584, 1998.
41. Loike, J.D.
and A. Steinberg. Medical Ethics Series: Human cloning: a scientific and Jewish perspective. Tradition, 32: Aug. 1998
42. Maxeiner, H., Huseman, J. Thomas, C.A., Loike, J.D.
, El Khoury, J., Silverstein, S.C. Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low density lipoproteins and secretion of H2O2. J. Exp. Med. 188:2257-2265, 1998.
43. Loike, J.D
, L. Cao, Y. M. Li, S. Budhu, E.E. Marcantonio, J. El Khoury, S. Hoffman, T. A. Yednock and S.C. Silverstein. Chemoattractants differentially stimulate 1 integrin activity to regulate neutrophil migration through fibrin. J. Cell Biol. 144: 1047-1056, 1999.
44. Evans, M. C. Gurer, J.D. Loike
, A. Schnieke, E.A. Schon. Mitochondrial genotypes in nuclear transfer-derived cloned sheep. Nature Genetics 23:90-93, 1999.
45. Steinberg, A. and J.D. Loike
. Medical Ethics Series. Human Cloning: Scientific, Ethical and Jewish Perspectives Assia IV, 1998.
46. Thienel, U. J.D. Loike,
and M.J. Yellin. CD154 (CD40L) induces human endothelial cell chemokine production and migration of leukocytes subsets. Cell Immunol. 198:87-95, 1999.
47. Loike, J.D.
. Medical Ethics Series: Is a Human Clone a Golem? The Torah U-Madda Journal 9:236-245, 2000.
48. Husemann, J., J.D. Loike
, T. Kodama, and S.C. Silverstein. Scavenger receptor B1 mediates adhesion and reactive oxygen species secretion by newborn murine microgila on fibrillar -amyloid-containing matrices. J. Neuroloimmunology 114:142-150, 2001.
49. Loike, J.D
, L. Cao, S. Budhu, S. Hoffman, and S.C. Silverstein. Blockade of 51 integrins reverses tenascin’s inhibitory effect on chemotaxis of human monocytes and polymorphonuclear leukocytes through three-dimensional Gels of extracellular matrix proteins. J. Immunology 166:7534-7542, 2001.
50. Loike, J.D. Bioethical and legal boundaries of human cloning. American Society of Cell Biology Newsletter, 24:7-10, 2001.
51. Berger,M., S. Budhu, Y. Li, D. Loike, S. C. Silverstein, and J.D. Loike.
Differential effects of chemoattractants and matrix proteins on PMN H2O2 production: chemoattractant Gi-coupled receptors activate qualitatively different signals. J. Leukocyte Biology 71:798-806, 2002.
52. Li, Y., J. D. Loike
, L. Cao, S. C. Silverstein. The bacterial peptide fMLP inhibits killing of S.epidermidis
by human neutrophils in fibrin gels. J Immunol. 168:816-24, 2002.
53. Yongmei Li, Arthur Karlin, John .D. Loike
, and S.C. Silverstein. A critical concentration of neutrophils is required for efficient bacterial killing in suspension . Proc. Natl Acad Sci. 99:8289-94, 2002.
54. Loike, J. D.
and M.D. Tendler. Homo Sapiens:
Reformulating the Definition Of Species. Kennedy Institute of Ethics Journal, 12: 343-350, 2002.
55. Husemann, J., J.D. Loike
and S. C. Silverstein. Scavenger receptors in neurobiology: Their role on microglia and other cells of the nervous system. Gila. 40:195-205, 2002.
56. Wyss-Coray, Tony, John D. Loike
, Thomas Brionne, Emily Lu, Samuel C. Silverstein and Jens Husemann. Binding, uptake and degradation of amyloid-ß1-42 by adult murine astrocytes. Nature Medicine 4:453-457. 2003
57. Loike, J.D. Why is This Gene Different From All Other Genes? The Jewish Press, March 7th, 2003.
58. Loike, J.D. Hello Dolly, Goodbye Dolly. Columbia College Journal of Bioethics. Vol 1:pg 7-9, Fall 2003.
59. Loike, J.D. and Tendler, M.D. Halakhic Definition of Homo Sapiens
. Tradition, 37:2 pg 1-19, 2003.
60. Loike, J.D.
Reproducible Cloning. Columbia University Journal of Bioethics
. 2:7-9, 2003.
61. Yongmei Li, A. Karlin, J.D. Loike
, and S.C. Silverstein. A critical concentration of neutrophils is required for efficient bacterial killing in fibrin gels J Exp Med, 200:613-622, 2004.
62. Loike, J.D., D.Y. Shabtai, R. Neuhut, S. Malitzky, E. Lu, J. Husemann, I. J. Goldberg, and S.C. Silverstein. Statin inhibition of Fc-receptor mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. Arterioscler Thromb Vasc Biol 24:2051-2057,2004.
63. Loike, J.D.
Is a Human Clone a Golem? In Mind, Body and Judaism: The Interaction of Jewish Law With Psychology and Biology (eds David Shatz, Joel B. Wolowelsky). Ktav Pub Inc pg 300-310, 2004.
64. Steinberg, A. and Loike, J.D.
, Human cloning in Jewish Medical Ethics Vol 1 (M. Halperin, D. Fink, and S. Glick eds) The Schlesinger Institute, Jerusalem 2004 pg 192-209.
65. Loike, J.D.,
A rabbinical-scientist dialogue on the Ethical challenge in stem cell research and in vitro fertilization. The Jewish Press, September 30, 2005.
66. Loike, J.
D., et al., Are your genes up for the job? Columbia University Journal of Bioethics 5:67-69, 2006.
67. Loike, J.D.
BIOCEP: Cross Cultural Education in Bioethics. Columbia University Journal of Bioethics 6:75, 2007.
68. Loike, J.D.,
et al., e-BABY: Your Source for Designer Babies. Columbia University Journal of Bioethics 6, 40-41, 2007.
69. Loike, J.D.
and Tendler, M.D. Ethical Dilemmas in Stem Cell Research: Human-Animal Chimeras. Tradition, 40:20-50, 2007.
70. Loike, J.D.
and Tendler, M.D. Molecular Genetics, Evolution, and Torah Principles. The Torah U’Madda Journal, 14:173-192, 2006-07.
71. Fischbach, R.L. and Loike, J. D.
Postmortem Fatherhood: Life After Life. Lancet 37:2166-2177, 2008.
72. Talloczy, Z., Santambrogio, L., Joset, D., Ray, Y., Martinez, J., Mizushima, N., Loike, J.D.,
David Sulzer. Methamphetamine inhibits antigen processing and presentation in dendritic cells and phagocytosis by macrophages. PLOS-Pathogen 4:28-48, 2008.
73. Loike, J.D.
, Fischbach, Ruth, L. End of Life Issues from a Jewish Perspective. The Jewish Press June 25th, 2008, pg 16.
74. Loike, J.D.,
and Tendler, M.D. Reconstituting a Human Brain in Animals: a Jewish Perspective on Human Sanctity and Chimera Research. Kennedy Institute of Ethics Journal, 18:347-367, 2008.
75. Loike, J.D.,
Tendler, M.D. Ethical/Halachic Challenges Emerging From Stem Cell Research. Jewish Political Studies Review (Fall 2009).
76. Loike, J.D.
and Tendler, M.D. Behavior Genetics: A Quest for an Ethical Genome. Assia- Jewish Medical Ethics, 7:14-23 2009.
77. Loike, J.D
. Fischbach, R.L. Benefits of the stem cell ban. The Scientist June 8th 2009. http://www.the-scientist.com/news/display/55752/
78. Silverstein, S.C. Dubner, J., Miller, J. Glied, S., Loike, J.D.
Teacher Research Program Participation Improves Their Students’ Achievement in Science. Science 326: 440-442, 2009.
79. Loike, J.D.
Tendler, M.D. Fischbach, R.L. Jewish views on the beginnings of human life and the use of medical intervention to produce children. American Journal of Bioethics, 9:45-47, 2009.
80. Loike, J.D.
Internal and external forces influencing moral decision-making processes. (To be published in 2011.
81. Budhu, S., Loike, J.D.,
Constantinescu, A., Pandolfi, A., Clynes, R., and Silverstein, S.C. CD8+ T-cell concentration determines the efficiency of killing of cognate antigen-expressing syngeneic mammalian cells in vitro and in vivo. Journal of Experimental Medicine, 207:223-235, 2010.
82. Zhang, W., Phillips, K., Wielgus, A.R., Liu, J., Albertini, A., Zucca, F.A., Faust, R., Qian, Y., Miller, D.S., Chignell, C.F., Wilson, B., Jackson-Lewis, V., Przedborski,S., Joset, D., Loike, J.D
., Hong, J., Sulzer, D., and Zecca,.L. Microglial Mac-1 is involved in phagocytosis of neuromelanin and neuronal death: implications for Parkinson's disease’’ Neurotoxicity Research Jan;19(1):63-72, 2010.
83. Arslanoglu, J. Schultz, J., Loike, J.D. and Peterson, K. Immunology and Art: Using Antibody-based Techniques to Identify Proteins and Gums in Binding Media and Adhesives. J. Biosci. 35(1), March 2010.
84. Loike, J.D
., Gillick, M., Prager, K., Mayer, S., Simon, J. Steinberg, A., Tendler, M.D., Willig, M., and Fischbach, R.L. The Critical Role of Religion: Caring for the Dying Patient from an Orthodox Jewish Perspective. Journal of Palliative Medicine, vol 13: 1267-1271, 2010.
85. Loike, J.D.
DNA Technology: The power to detect and create. The Jewish Press pg 18, July 2, 2010.
86. Arslanoglu, J., Zaleski, S., Loike, J.D.
An improved method of protein localization in artworks through SERS nanotag-complexed antibodies. Analytical and Bioanalytical Chemistry, 399; 2997-3010, 2011.
87. Kothari1, K., Zumeris, J., Jacob, H., Loike
, J.D. Surface Acoustic Waves cause Net Reduction in Mouse and Human Melanoma Growth in vitro. Columbia Undergraduate Science Journal, 5:35-41, 2011.
88. Loike, J.D. Tendler, M.D. Halachic Bioethics Guidelines Journal of Halacha in Contemporary Society, Journal of Halacha in Contemporary Society 16:92-118, 2011.
89. Loike, J.D. The Power to Predict: Using DNA Technologies to Assess the Genetics and Health of a Fetus. B’Or Ha’Torah. Jan, 2012.
90. Miller, J. Loike, J.D. BioCEP: A Model Educational Program for Cross-cultural Bioethics. Cambridge Quarterly of Healthcare Ethics, 21:409-415, 2012.
91. Phani, S., Loike, J.D., Przedborski, S. Neurodegeneration and Inflammation in Parkinson’s Disease. Parkinsonism Related Disorders. 2012 Jan;18 Suppl 1:S207-9.
92. Loike, J.D.
The Evolving Bioethical Landscape of Human-Animal Chimeras, in "Human Dignity in Bioethics: From Worldviews to the Public Square." (Edited by Steve Dilley and Nathan Palpant). 2013.
93. Loike, J. L., and Fischbach, R. L. Ethical Challenges in Biodefense and Bioterrorism, J Bioterr Biodef, 2013, S01-S12.
94. Loike, J.D., Plitt, A., Kothari, K., Zumeris
, J., Budhu, S., Kavalus, K., Ray, Y., and Jacob, H.
Surface Acoustic Waves Enhance Neutrophil Killing of Bacteria, PLOS One, 2013 http://dx.plos.org/10.1371/journal.pone.0068334.95.
Loike, J.D., Rush, B.S., Schweber, A., Fischbach, R. L. Lessons Learned from Undergraduate Students in Designing a Science-based Course in Bioethics, Cell Biology Education—A Journal of Life Science Education, 12:701-710, 2013.96.
Loike, J.D. and Miller, J. Personalized Medicine, Encyclopedia of Bioethics, In Press 2013.
97. Loike, J.D. Tendler, M.D. Halachic Perspectives of Gestational Surrogacy, Hakirah, 16:115-132, 2013.
98. Loike, J.D. Tendler, M.D. Becoming a Surrogate for an Infertile Jewish Couple. Journal of Halacha and Contemporary Society, 66:5-21, 2013.
99. Loike, J.D., Hirano, M., Margalit, H., Three-Way Parenthood: dealing with the logistics of embryos created by three-parent IVF technologies that avoid the transmission of mitochondrial disease. Oct 1, The Scientist, 2013.
100. Loike, J., and Fischbach, R.L. New Ethical Horizons in Gestational Surrogacy, J IVF Reprod Med Genet 1: 109, 2013. doi:10.4172/jfiv.1000109
101. Margolit, Y., Levy, O., Loike, J.D., Advanced Reproductive Technologies: Reevaluating Modern Parentage, Harvard Journal of Law and Gender, 107-141, 2014.
102. PrabhuDas, M., Bowdish, D., Drickamer, K., Febbraio, M., Herz, J., Kobzik , L., Krieger, M., Loike, J.D., Means, T.K, Moestrup, S., Post, S., Sawamura, T., Silverstein, S.C., Wang, X.Y., El Khoury, J., Standardizing Scavenger Receptor Nomenclature, J. Immunology, Feb, 27, 2014. http://www.jimmunol.org/content/192/5/1997.full.pdf+html
103. Loike, J.D. and Miller, J. Time for Translational Biotechnology: When is it ethical to begin clinical trials?? The Scientist, April 1, 2014, http://www.the-scientist.com/?articles.view/articleNo/39179/title/Opinion--Translational-Biotechnology/
104. Cebrián, C., Loike, J.D., Sulzer, D. Role of Neuroinflammation in Parkinson’s disease: a cause or result. Behavioral Neurobiology of Huntington's and Parkinson's Disease, Volume Editors: Cenci MA and Nguyen H., in Series: Current Topics in Behavioral Neurosciences, Series Editors: Mark Geyer, Bart Ellenbroek and Charles Marsden. 2014.
105. Cebrián, C., Zucca, F.A., Mauri, P., Steinbeck, J.A. Studer, L., Scherzer, C.R., Kanter, E., Budhu, S. Mandelbaum, J., Vonsattel, J.P., Zecca, L., Loike, J.D., Sulzer, D., MHC-I expression renders
catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nature Communications, April 14, 2014, http://www.ncbi.nlm.nih.gov/pubmed/24736453.
106. Stoltz-Loike, M., and Loike, J.D., Online Education in Bioethics. in "Bioethics Challenges in a Globalized World” Wiley and Sons, 2014.
107. Zivotofsky, A. and Loike, J.D. Cultural influences on Translational Gestational Surrogacy, AJOB, 14:44-46, 2014.
108. Fischbach, R.L., and Loike, J.D. Ties that Bind, AJOB, 14:35-36, 2014.
109. Lee, H.Y., Granzotto, C., Schultz, J., Loike, J.D., Arslanoglu, J. Optimizing ELISA Methodology for the Analysis of Artworks, Accepted for publication in Analytical and Bioanalytical Chemistry. 2014.
110. Loike, J.D. Ethical Semantics in Science, Submitted, 2014.
111. Loike, J.D. and Tendler, M.D. Creating Human Embryos Using Reproductive Cloning
Technologies. Journal of Halacha and Contemporary Society, Spring, 2014.
112. Peter Huebener, Jean-Philippe Pradere, Celine Hernandez, Geum-Youn Gwak,
Jorge Matias Caviglia, Xueru Mu, John D. Loike and Robert F. Schwabe, The HMGB1-RAGE axis promotes neutrophil recruitment and amplification of injury following necrosis. Nature Medicine submitted 2014.BOOKS
Lignans: Chemical, Biological and Clinical Properties (Chemistry and Pharmacology of Natural Products) by David C. Ayres and John D. Loike Cambridge Press 1990
Lignans: Chemical, Biological and Clinical Properties (Chemistry and Pharmacology of Natural Products) by David C. Ayres and John D. Loike Cambridge Press 2008
Frontiers in Bioethics by John D. Loike and Ruth L. Fischbach 2013
Bioethics - New Frontiers in Jewish Ethics by John D. Loike and Rabbi Moshe Tendler. YU Press 2014
Translation Science and Engineering by John D. Loike, Jacob Aruldhas, and Beatrice Gonard. 2015 INVITED LECTURES (2012-2014)
1. January 1, 2012. The Chosen Womb: Ethics of Gestational Surrogacy. Bar-Ilan University, Tel Aviv, Israel.
2. February 2, 2012. T- Cell Mediated Killing of Neurons in Parkinson’s Disease. Touro College, New York.
3. April 23, 2012. Cancer and Immunology. New Rochelle High School, Scarsdale, New York.
4. June 20, 2012. Ethics of Stem Cell Research. Columbia College, New York, NY.
5. August 7, 2012. Online Science Eduation. Institute of Online Learning, Mahidol University, Bangkok, Thailand.
6. August 9, 2012. Online Learning on the Ethics of Stem Cell Research. Faculty of Science, Siriraj Medical School, Mahidol University, Bangkok, Thailand.
7. August 18, 2012. The Jewish Perspective on Gestational Surrogacy. Young Israel of Jamaica Estates, Jamaica, New York.
8. October 10, 2012. Is Parkinson’s Disease an Autoimmune Disorder. Columbia College, New York, NY.
9. October 15, 2012. Inaugural Address for the International Conference on Biothreats and Biodefense, Chicago, Il.
10. October 17, 2012. Symposium leader and presenter on The Ethical Challenges of Bioterror, Chicago Il.
11. November 5, 2012. Ethics of Stem Cell Medical Tourism, Fordum University, New York, NY.
12. November 13, 2012. Ethical Perspective on Gestational Surrogacy. Stern College of Yeshiva University, New York, NY.
13. November 28-29, 2012. Panelist on a special NIH sponsored workshop on “Classification of Scavenger like Receptors. Bethesda, MD.
14. November 30, 2012. The Jewish Perspective on Gestational Surrogacy. Congregation Shomrei Emunah, Baltimore, MD.
15. December 4, 2012. Title: Stem Cells: Biology, Bioethics, and Applications – A Comprehensive Online Course. Advancing Ethical Research conference, PRIM&R, San Diego, CA.
16. December, 17, 2012. T-cells Mediate Substantia Nigra Neurodegeneration in Parkinson's Disease. American Society of Cell Biology, San Francisco, CA.
17. December 19, 2012. Lessons learned from undergraduate students in designing a science course in bioethics . American Society of Cell Biology, San Francisco, CA.
18. February 16, 2013. Gestational Surrogacy. Bar-Ilan University, Ramat Gan, Israel.
19. June 5, 2013. Ethics of Human Cloning, Bar-Ilan University, Ramat Gan, Israel.
20. July 30- Aug 1, 2013. Coordinating two courses for University of Kerela. Social Responsibility and Translational engineering.
21. Aug, 7, 2013. Online blended learning in bioethics, Mahidol University, Bangkok, Thailand.
22. Aug. 9, 2013. Is Parkinson’s disease auto-immune? Mahidol University, Bangkok, Thailand
23. Aug. 17, 2013. Ethical Perspectives on human cloning. Young Israel of Jamaica Estates, Queens, NY
24. Oct. 3, 2013. Session Chair on the Ethics of Parkinson’s disease. World’s Parkinson’s Congress
25. Oct. 22, 2013. Human Cloning. Lander College for Men. Queens, NY.
26. Oct. 29, 2013. Human Cloning. Lander College for Women, New York City, NY
27. Oct 25, 2013. Maternal-Fetal Cell Exchange in Surrogates. 18th World Congress on
Controversies in Obstetrics, Gynecology & Infertility. Vienna, Austria.
28. Dec. 3, 2013 Human Cloning. Columbia College
29. Dec. 10, 2013. Human Cloning. Tenth Miami International Conference on Torah and Science. Miami, Florida.
30. Feb. 26, 2014 Bioethics of Reproduction Medicine. Master’s Program in Bioethics, Columbia University College of Continuing Education
31. March 3, 2014 Emerging Technologies in Reproductive Medicine, Florida International University, Miami, Fl
32. May 15, 2014, Ethical challenges of Human cloning. The Jewish Center, NYC, NY